:root{
  --bg: #FEFEFC;
  --bg-alt: #F6F5F0;
  --card: #FFFFFF;
  --line: #E6E4DC;
  --line-strong: #D2CFC3;
  --ink: #1B1D1E;
  --text-mid: #585B58;
  --text-dim: #91948E;
  --cherry: #A6192E;
  --cherry-deep: #7E1224;
  --cool: #3E6670;
  --serif: "Fraunces", Georgia, serif;
  --sans: "Inter", -apple-system, BlinkMacSystemFont, sans-serif;
  --mono: "IBM Plex Mono", ui-monospace, monospace;
  --max: 1160px;
  --article-max: 760px;
}

*{ box-sizing:border-box; margin:0; padding:0; }
html{ scroll-behavior:smooth; }
@media (prefers-reduced-motion: reduce){
  html{ scroll-behavior:auto; }
  *{ animation-duration:0.001ms !important; animation-iteration-count:1 !important; transition-duration:0.001ms !important; scroll-behavior:auto !important; }
}

body{
  background:var(--bg);
  color:var(--ink);
  font-family:var(--sans);
  font-size:16px;
  line-height:1.65;
  -webkit-font-smoothing:antialiased;
}

a{ color:inherit; }
img,svg{ display:block; max-width:100%; }
ul{ list-style:none; }

.wrap{ max-width:var(--max); margin:0 auto; padding:0 32px; }
@media (max-width:640px){ .wrap{ padding:0 20px; } }

.skip-link{
  position:absolute; left:-999px; top:0; background:var(--ink); color:#fff;
  padding:12px 18px; z-index:200; font-family:var(--sans); font-weight:600;
}
.skip-link:focus{ left:16px; top:16px; }

:focus-visible{ outline:2px solid var(--cool); outline-offset:3px; }

h1,h2,h3{ font-family:var(--serif); font-weight:400; letter-spacing:0; color:var(--ink); }

.eyebrow{
  font-family:var(--mono); font-size:0.76rem; letter-spacing:0.03em;
  color:var(--text-dim); margin-bottom:14px; display:block; text-transform:uppercase;
}

/* ---------- Header ---------- */
header.site-header{
  position:fixed; top:0; left:0; right:0; z-index:100;
  background:rgba(254,254,252,0.92); backdrop-filter:blur(8px);
  border-bottom:1px solid var(--line);
}
.nav-row{ display:flex; align-items:center; justify-content:space-between; height:70px; }
.wordmark{
  font-family:var(--serif); font-size:1.2rem; font-weight:500; color:var(--ink);
  text-decoration:none;
}
nav.primary-nav{ display:flex; align-items:center; gap:26px; }
nav.primary-nav a{
  font-size:0.89rem; text-decoration:none; color:var(--text-mid);
  transition:color 0.15s ease;
}
nav.primary-nav a:hover{ color:var(--ink); }
nav.primary-nav a.active{ color:var(--ink); font-weight:600; }
.lang-switch{
  font-family:var(--mono) !important; font-size:0.76rem !important;
  border:1px solid var(--line-strong); padding:5px 9px; border-radius:2px; color:var(--text-mid) !important;
}
.nav-cta{
  font-family:var(--sans); font-weight:600; font-size:0.86rem;
  color:#fff !important; background:var(--cherry);
  padding:9px 17px; border-radius:2px; text-decoration:none;
}
.nav-cta:hover{ background:var(--cherry-deep); }
.menu-btn{
  display:none; background:none; border:1px solid var(--line-strong); color:var(--ink);
  width:40px; height:40px; border-radius:2px; cursor:pointer; font-size:1.05rem;
}
@media (max-width:960px){
  nav.primary-nav{
    position:fixed; top:70px; left:0; right:0; bottom:0; background:var(--bg);
    flex-direction:column; align-items:flex-start; padding:32px 24px; gap:22px;
    transform:translateX(100%); transition:transform 0.25s ease; overflow-y:auto;
  }
  nav.primary-nav.open{ transform:translateX(0); }
  nav.primary-nav a{ font-size:1.1rem; }
  .menu-btn{ display:block; }
}

/* ---------- Hero (homepage) ---------- */
.hero{ padding:150px 0 88px; }
.hero-grid{ display:grid; grid-template-columns:1.05fr 0.95fr; gap:56px; align-items:center; }
@media (max-width:920px){ .hero-grid{ grid-template-columns:1fr; gap:44px; } }
.hero h1{ font-size:clamp(1.9rem, 3.4vw, 2.55rem); line-height:1.22; max-width:16ch; }
.hero .lede{ margin-top:22px; font-size:1.04rem; color:var(--text-mid); max-width:46ch; line-height:1.7; }
.hero .cta-row{ margin-top:32px; display:flex; gap:14px; flex-wrap:wrap; }
.hero .meta-line{ margin-top:26px; font-family:var(--mono); font-size:0.78rem; color:var(--text-dim); }

.signal-panel{ background:var(--card); border:1px solid var(--line); border-radius:3px; padding:24px 22px 18px; }
.signal-panel .cap{ display:flex; justify-content:space-between; font-family:var(--mono); font-size:0.72rem; color:var(--text-dim); margin-bottom:14px; }
.signal-panel .legend{ display:flex; gap:20px; margin-top:12px; }
.legend-item{ display:flex; align-items:center; gap:8px; font-family:var(--mono); font-size:0.74rem; color:var(--text-mid); }
.legend-swatch{ width:14px; height:2px; }
.signal-path{ stroke-dasharray:900; stroke-dashoffset:900; animation:draw 1.9s ease-out forwards; }
.signal-path.delay{ animation-delay:0.3s; }
@keyframes draw{ to{ stroke-dashoffset:0; } }
@media (prefers-reduced-motion: reduce){ .signal-path{ stroke-dashoffset:0; animation:none; } }

/* ---------- Page header (subpages) ---------- */
.page-header{ padding:150px 0 52px; background:var(--bg-alt); border-bottom:1px solid var(--line); }
.page-header h1{ font-size:clamp(1.8rem, 3vw, 2.3rem); line-height:1.2; max-width:22ch; }
.page-header .lede{ margin-top:16px; font-size:1.02rem; color:var(--text-mid); max-width:62ch; line-height:1.7; }
.breadcrumb{
  font-family:var(--mono); font-size:0.78rem; color:var(--text-dim); text-decoration:none;
  display:inline-block; margin-bottom:20px;
}
.breadcrumb:hover{ color:var(--ink); }

/* ---------- Section shells ---------- */
section{ padding:92px 0; }
@media (max-width:640px){ section{ padding:64px 0; } }
.section-alt{ background:var(--bg-alt); }
h2.section-title{ font-size:clamp(1.55rem, 2.5vw, 2rem); line-height:1.25; max-width:22ch; font-weight:400; }
.section-head{ max-width:640px; margin-bottom:52px; }
.section-head p{ margin-top:14px; font-size:1rem; color:var(--text-mid); line-height:1.7; }

/* ---------- Long-form article content (subpages) ---------- */
.article{ max-width:var(--article-max); }
.article h2{ font-size:1.35rem; font-weight:500; margin-top:52px; margin-bottom:16px; }
.article h2:first-child{ margin-top:0; }
.article h3{ font-family:var(--sans); font-size:1rem; font-weight:600; color:var(--ink); margin-top:30px; margin-bottom:10px; }
.article p{ font-size:0.98rem; color:var(--text-mid); line-height:1.8; margin-top:14px; }
.article p:first-of-type{ margin-top:0; }
.article ul.plain-list{ margin-top:16px; display:flex; flex-direction:column; gap:12px; }
.article ul.plain-list li{ display:flex; gap:12px; font-size:0.96rem; color:var(--ink); line-height:1.6; }
.article ul.plain-list li .bullet{ width:5px; height:5px; border-radius:50%; background:var(--line-strong); margin-top:9px; flex-shrink:0; }
.article strong{ color:var(--ink); font-weight:600; }
.article .pull-quote{
  font-family:var(--serif); font-style:italic; font-weight:400; font-size:1.2rem; line-height:1.55;
  color:var(--ink); border-left:2px solid var(--cherry); padding-left:20px; margin:32px 0;
}
.article .callout{
  background:var(--bg-alt); border:1px solid var(--line); border-radius:3px; padding:20px 22px; margin:28px 0;
}
.article .callout p{ margin-top:0; font-size:0.93rem; }
.article .callout p + p{ margin-top:10px; }

/* ---------- Stat row ---------- */
.stat-row{ display:grid; grid-template-columns: 1.3fr 1fr 1fr; gap:1px; background:var(--line); border:1px solid var(--line); margin-bottom:48px; }
@media (max-width:760px){ .stat-row{ grid-template-columns:1fr; } }
.stat-row.stat-row-3{ grid-template-columns:1fr 1fr 1fr; }
.stat-row.stat-row-4{ grid-template-columns:1fr 1fr 1fr 1fr; }
@media (max-width:760px){ .stat-row.stat-row-4{ grid-template-columns:1fr 1fr; } }
.stat-cell{ background:var(--card); padding:32px 28px; }
.stat-cell .num{ font-family:var(--serif); font-weight:500; font-size:2.15rem; color:var(--cherry); line-height:1; }
.stat-cell .num.small{ font-size:1.6rem; }
.stat-cell .label{ margin-top:11px; font-size:0.93rem; color:var(--text-mid); max-width:26ch; }

.problem-body{ display:grid; grid-template-columns:1fr 1fr; gap:44px; align-items:start; }
@media (max-width:800px){ .problem-body{ grid-template-columns:1fr; } }
.problem-body p{ font-size:0.99rem; line-height:1.75; color:var(--text-mid); }
.problem-body p + p{ margin-top:15px; }
.pull-quote{
  font-family:var(--serif); font-style:italic; font-weight:400; font-size:1.22rem; line-height:1.55;
  color:var(--ink); border-left:2px solid var(--cherry); padding-left:20px;
}

/* ---------- Idea / flow ---------- */
.idea-copy{ max-width:640px; }
.idea-copy p{ color:var(--text-mid); font-size:1.02rem; line-height:1.75; margin-top:14px; }
.flow{ margin-top:56px; display:grid; grid-template-columns:1fr auto 1fr auto 1fr; gap:16px; align-items:center; }
@media (max-width:820px){ .flow{ grid-template-columns:1fr; } .flow .arrow{ transform:rotate(90deg); justify-self:center; } }
.flow-step{ background:var(--card); border:1px solid var(--line); border-radius:3px; padding:24px 20px; }
.flow-step .step-label{ font-family:var(--mono); font-size:0.7rem; color:var(--text-dim); letter-spacing:0.04em; }
.flow-step h3{ font-size:1.05rem; margin-top:9px; font-weight:500; }
.flow-step p{ margin-top:9px; font-size:0.9rem; color:var(--text-mid); line-height:1.55; }
.arrow{ color:var(--line-strong); font-size:1.3rem; }

/* ---------- Engines ---------- */
.engines-grid{ display:grid; grid-template-columns:1fr 1fr; gap:1px; background:var(--line); border:1px solid var(--line); }
@media (max-width:820px){ .engines-grid{ grid-template-columns:1fr; } }
.engine-panel{ background:var(--card); padding:36px 32px; }
.engine-panel .engine-tag{ font-family:var(--mono); font-size:0.74rem; color:var(--text-dim); letter-spacing:0.04em; }
.engine-panel h3{ font-size:1.35rem; margin-top:9px; font-weight:500; }
.engine-panel .desc{ margin-top:13px; color:var(--text-mid); font-size:0.96rem; line-height:1.7; }
.engine-panel ul{ margin-top:20px; }
.engine-panel li{ font-size:0.92rem; color:var(--ink); padding:12px 0; border-top:1px solid var(--line); line-height:1.55; }
.engine-panel li b{ font-weight:600; display:block; margin-bottom:3px; }
.flywheel-note{ margin-top:26px; padding-top:26px; border-top:1px solid var(--line); font-size:0.9rem; color:var(--text-mid); max-width:760px; }

/* ---------- Data table (competitive landscape etc.) ---------- */
.data-table{ width:100%; border-collapse:collapse; margin-top:20px; font-size:0.88rem; }
.data-table th{
  font-family:var(--mono); font-size:0.72rem; text-transform:uppercase; letter-spacing:0.02em;
  color:var(--text-dim); text-align:left; padding:10px 14px; border-bottom:1px solid var(--line-strong);
}
.data-table td{ padding:12px 14px; border-bottom:1px solid var(--line); color:var(--text-mid); vertical-align:top; }
.data-table td:first-child{ color:var(--ink); font-weight:600; }
.data-table-wrap{ overflow-x:auto; margin:24px 0; }

/* ---------- Evidence console ---------- */
.evidence-console{ background:var(--card); border:1px solid var(--line); border-radius:3px; padding:36px; }
@media (max-width:640px){ .evidence-console{ padding:24px 20px; } }
.console-top{ display:flex; justify-content:space-between; align-items:baseline; flex-wrap:wrap; gap:10px; border-bottom:1px solid var(--line); padding-bottom:18px; margin-bottom:30px; }
.console-top .dataset-id{ font-family:var(--mono); font-size:0.82rem; color:var(--ink); }
.console-top .dataset-meta{ font-family:var(--mono); font-size:0.76rem; color:var(--text-dim); }
.console-grid{ display:grid; grid-template-columns:1fr 1fr; gap:40px; }
@media (max-width:860px){ .console-grid{ grid-template-columns:1fr; } }
.auc-bars{ display:flex; flex-direction:column; gap:19px; }
.bar-row .bar-label{ display:flex; justify-content:space-between; font-family:var(--mono); font-size:0.8rem; color:var(--text-mid); margin-bottom:7px; }
.bar-row .bar-label b{ color:var(--ink); font-weight:600; }
.bar-track{ height:8px; background:var(--bg-alt); border:1px solid var(--line); border-radius:2px; overflow:hidden; }
.bar-fill{ height:100%; width:0; transition:width 1.1s cubic-bezier(.2,.7,.2,1); }
.bar-fill.baseline{ background:var(--line-strong); }
.bar-fill.full{ background:var(--cool); }
.bar-fill.signature{ background:var(--cherry); }
.bar-row .bar-sub{ margin-top:7px; font-size:0.8rem; color:var(--text-dim); }
.gene-block{ margin-bottom:20px; }
.gene-block .gh{ font-family:var(--mono); font-size:0.74rem; margin-bottom:9px; letter-spacing:0.02em; }
.gene-block.inflam .gh{ color:var(--cherry); }
.gene-block.lymph .gh{ color:var(--cool); }
.gene-chips{ display:flex; flex-wrap:wrap; gap:8px; }
.gene-chip{ font-family:var(--mono); font-size:0.8rem; padding:5px 9px; border-radius:2px; border:1px solid var(--line-strong); color:var(--ink); background:var(--bg-alt); }
.evidence-footnote{ margin-top:28px; padding-top:22px; border-top:1px solid var(--line); font-size:0.88rem; color:var(--text-mid); line-height:1.65; }
.evidence-footnote a{ color:var(--cool); text-decoration:underline; }

/* ---------- Scientific rationale tabs / citations ---------- */
.rationale-block{ margin-top:40px; }
.rationale-tabs{ display:flex; gap:0; border-bottom:1px solid var(--line); margin-bottom:26px; flex-wrap:wrap; }
.rationale-tab{
  font-family:var(--sans); font-size:0.87rem; font-weight:600; color:var(--text-mid);
  background:none; border:none; padding:11px 4px; margin-right:26px; cursor:pointer;
  border-bottom:2px solid transparent; transition:color 0.15s ease, border-color 0.15s ease;
}
.rationale-tab:hover{ color:var(--ink); }
.rationale-tab.active{ color:var(--ink); border-bottom-color:var(--cherry); }
.rationale-panel p{ font-size:0.95rem; color:var(--text-mid); line-height:1.75; max-width:720px; }
.citation-list{ margin-top:18px; display:flex; flex-direction:column; gap:10px; }
.citation-card{
  display:flex; flex-direction:column; gap:3px; padding:14px 16px; border:1px solid var(--line);
  border-radius:3px; background:var(--card); text-decoration:none; transition:border-color 0.15s ease;
}
.citation-card:hover{ border-color:var(--cool); }
.citation-title{ font-size:0.91rem; color:var(--ink); font-weight:500; line-height:1.4; }
.citation-meta{ font-family:var(--mono); font-size:0.75rem; color:var(--text-dim); }

/* ---------- Impact ---------- */
.impact-grid{ display:grid; grid-template-columns:1fr 1fr; gap:1px; background:var(--line); border:1px solid var(--line); }
@media (max-width:820px){ .impact-grid{ grid-template-columns:1fr; } }
.impact-col{ background:var(--card); padding:34px 30px; }
.impact-col h3{ font-size:1.18rem; font-weight:500; }
.impact-col .sub{ font-family:var(--mono); font-size:0.74rem; color:var(--text-dim); margin-bottom:8px; display:block; letter-spacing:0.03em; }
.impact-list{ margin-top:20px; display:flex; flex-direction:column; gap:17px; }
.impact-item{ display:flex; gap:13px; }
.impact-item .bullet{ width:5px; height:5px; border-radius:50%; background:var(--line-strong); margin-top:9px; flex-shrink:0; }
.impact-item p{ font-size:0.93rem; color:var(--ink); line-height:1.55; }
.impact-item p .fine{ display:block; color:var(--text-mid); font-size:0.86rem; margin-top:3px; }

/* ---------- Demo CTA band ---------- */
.demo-band{ background:var(--bg-alt); border-top:1px solid var(--line); border-bottom:1px solid var(--line); }
.demo-band-inner{ display:grid; grid-template-columns:1.2fr 0.8fr; gap:40px; align-items:center; }
@media (max-width:820px){ .demo-band-inner{ grid-template-columns:1fr; } }
.demo-band h2{ font-size:clamp(1.5rem,2.6vw,1.95rem); max-width:16ch; }
.demo-band p{ margin-top:16px; color:var(--text-mid); font-size:0.99rem; max-width:52ch; line-height:1.7; }
.demo-band .cta-row{ margin-top:26px; display:flex; gap:14px; flex-wrap:wrap; }
.demo-note{ font-family:var(--mono); font-size:0.78rem; color:var(--text-dim); margin-top:16px; }
.demo-card{ border:1px solid var(--line); border-radius:3px; padding:24px; background:var(--card); }
.demo-card .row{ display:flex; justify-content:space-between; padding:10px 0; border-top:1px solid var(--line); font-family:var(--mono); font-size:0.8rem; gap:12px; }
.demo-card .row:first-child{ border-top:none; }
.demo-card .row span:first-child{ color:var(--text-dim); }
.demo-card .row span:last-child{ color:var(--ink); text-align:right; }

/* ---------- Team ---------- */
.founder-block{ display:grid; grid-template-columns:88px 1fr; gap:28px; margin-bottom:56px; }
@media (max-width:600px){ .founder-block{ grid-template-columns:1fr; } }
.avatar{
  width:80px; height:80px; border-radius:50%; background:var(--card); border:1px solid var(--line-strong);
  display:flex; align-items:center; justify-content:center;
  font-family:var(--serif); font-size:1.5rem; color:var(--ink);
}
.founder-block h3{ font-size:1.22rem; font-weight:500; }
.founder-block .role{ font-family:var(--mono); font-size:0.8rem; color:var(--text-dim); margin-top:4px; display:block; }
.founder-block p{ margin-top:15px; font-size:0.96rem; color:var(--text-mid); line-height:1.75; max-width:64ch; }

/* ---------- Teaser grid (homepage overview cards) ---------- */
.teaser-grid{ display:grid; grid-template-columns:repeat(3,1fr); gap:1px; background:var(--line); border:1px solid var(--line); }
@media (max-width:900px){ .teaser-grid{ grid-template-columns:repeat(2,1fr); } }
@media (max-width:620px){ .teaser-grid{ grid-template-columns:1fr; } }
.teaser-card{
  background:var(--card); padding:30px 26px; text-decoration:none; display:flex; flex-direction:column;
  transition:background 0.15s ease;
}
.teaser-card:hover{ background:var(--bg-alt); }
.teaser-card .teaser-num{ font-family:var(--mono); font-size:0.74rem; color:var(--text-dim); }
.teaser-card h3{ font-size:1.12rem; font-weight:500; margin-top:10px; color:var(--ink); }
.teaser-card p{ margin-top:10px; font-size:0.88rem; color:var(--text-mid); line-height:1.55; flex-grow:1; }
.teaser-card .teaser-link{ margin-top:16px; font-size:0.82rem; font-weight:600; color:var(--cherry); }

/* ---------- Involved / market-data survey ---------- */
.involved-card{ border:1px solid var(--line); border-radius:3px; background:var(--card); overflow:hidden; }
.involved-card iframe{ width:100%; border:none; display:block; min-height:900px; }
.involved-fallback{ padding:32px; text-align:center; }
.involved-fallback p{ color:var(--text-mid); font-size:0.95rem; margin-bottom:16px; }
.why-list{ margin-top:24px; display:flex; flex-direction:column; gap:14px; max-width:620px; }
.why-list li{ display:flex; gap:12px; font-size:0.93rem; color:var(--ink); line-height:1.6; }
.why-list li .bullet{ width:5px; height:5px; border-radius:50%; background:var(--cherry); margin-top:9px; flex-shrink:0; }

/* ---------- Contact / Footer ---------- */
.contact-grid{ display:grid; grid-template-columns:1fr 1fr; gap:44px; }
@media (max-width:760px){ .contact-grid{ grid-template-columns:1fr; } }
.contact-info dl{ display:flex; flex-direction:column; gap:16px; margin-top:24px; }
.contact-info dt{ font-family:var(--mono); font-size:0.74rem; color:var(--text-dim); }
.contact-info dd{ margin-top:4px; font-size:0.98rem; }
.contact-info a{ text-decoration:none; border-bottom:1px solid var(--line-strong); }
.contact-info a:hover{ border-color:var(--cool); color:var(--cool); }

.mailto-card{ background:var(--card); border:1px solid var(--line); border-radius:3px; padding:28px; }
.mailto-card h3{ font-size:1.05rem; font-weight:500; }
.mailto-card p{ margin-top:9px; font-size:0.9rem; color:var(--text-mid); line-height:1.6; }
.mailto-card form{ margin-top:18px; display:flex; flex-direction:column; gap:12px; }
.mailto-card input, .mailto-card textarea{
  width:100%; background:var(--bg); border:1px solid var(--line-strong); border-radius:2px;
  color:var(--ink); padding:10px 12px; font-family:var(--sans); font-size:0.9rem;
}
.mailto-card textarea{ resize:vertical; min-height:84px; }
.mailto-card label{ font-size:0.78rem; color:var(--text-dim); font-family:var(--mono); }
.mailto-card .field{ display:flex; flex-direction:column; gap:6px; }

.btn{
  display:inline-flex; align-items:center; gap:8px; font-family:var(--sans);
  font-weight:600; font-size:0.92rem; padding:13px 22px; border-radius:2px;
  text-decoration:none; border:1px solid transparent; cursor:pointer;
  transition:background 0.15s ease, color 0.15s ease, border-color 0.15s ease;
}
.btn-primary{ background:var(--cherry); color:#fff; }
.btn-primary:hover{ background:var(--cherry-deep); }
.btn-ghost{ border-color:var(--line-strong); color:var(--ink); }
.btn-ghost:hover{ border-color:var(--text-mid); }

footer.site-footer{ border-top:1px solid var(--line); padding:32px 0; background:var(--bg); }
.footer-row{ display:flex; justify-content:space-between; align-items:center; flex-wrap:wrap; gap:14px; }
.footer-row p{ font-size:0.8rem; color:var(--text-dim); max-width:70ch; }
.footer-links{ display:flex; gap:20px; }
.footer-links a{ font-size:0.8rem; color:var(--text-dim); text-decoration:none; }
.footer-links a:hover{ color:var(--ink); }